SETD5 modulates homeostasis of hematopoietic stem cells by mediating RNA Polymerase II pausing in cooperation with HCF-1

Li, MK; Qiu, C; Bian, YJ; Shi, DY; Wang, BC; Ma, QY; Wang, XM; Shi, J; Zhang, LF; Ma, YW; Zhu, P; Cheng, T; Chu, YJ; Yuan, WP

Chu, YJ; Yuan, WP (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol, Natl Clin Res Ctr Blood Dis, State Key Lab Expt Hematol, Tianjin, Peoples R China.;Chu, YJ; Yuan, WP (通讯作者)，Chinese Acad Med Sci & Peking Union Med Coll, Blood Dis Hosp, Tianjin, Peoples R China.

LEUKEMIA, 2022; 36 (4): 1111

Abstract

SETD5 mutations were identified as the genetic causes of neurodevelopmental disorders. While the whole-body knockout of Setd5 in mice leads to embryon......

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