PROTAC targeted protein degraders: the past is prologue

Bekes, M; Langley, DR; Crews, CM

Bekes, M; Langley, DR (通讯作者)，Arvinas Inc, New Haven, CT 06511 USA.;Crews, CM (通讯作者)，Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA.;Crews, CM (通讯作者)，Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA.;Crews, CM (通讯作者)，Yale Univ, Dept Chem, New Haven, CT 06520 USA.

NATURE REVIEWS DRUG DISCOVERY, 2022; 21 (3): 181

Abstract

Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically be......

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