Lessons from CTLA-4 deficiency and checkpoint inhibition

Lo, B; Abdel-Motal, UM

Lo, B (reprint author), Sidra Med & Res Ctr, Res Branch, Div Translat Med, POB 26999, Doha, Qatar.

CURRENT OPINION IN IMMUNOLOGY, 2017; 49 ( ): 14

Abstract

CTLA-4 is a crucial negative regulator of immune responses. Absence of CTLA-4 in mice causes autoimmunity and lethal multiorgan lymphocytic infiltrati......

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