Structural Basis of Polyketide Synthase O-Methylation

Skiba, MA; Bivins, MM; Schultz, JR; Bernard, SM; Fiers, WD; Dan, QY; Kulkarni, S; Wipf, P; Gerwick, WH; Sherman, DH; Aldrich, CC; Smith, JL

Smith, JL (reprint author), Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA.; Smith, JL (reprint author), Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA.

ACS CHEMICAL BIOLOGY, 2018; 13 (12): 3221

Abstract

Modular type I polyketide synthases (PKSs) produce some of the most chemically complex metabolites in nature through a series of multienzyme modules. ......

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