WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death

Fischer, MM; Cancilla, B; Yeung, VP; Cattaruzza, F; Chartier, C; Murriel, CL; Cain, J; Tam, R; Cheng, CY; Evans, JW; O'Young, G; Song, XM; Lewicki, J; Kapoun, AM; Gurney, A; Yen, WC; Hoey, T

Fischer, MM; Hoey, T (reprint author), OncoMed Pharmaceut Inc, Redwood City, CA 94063 USA.

SCIENCE ADVANCES, 2017; 3 (6):

Abstract

The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely appreciated that the WNT......

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