Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway

Alecu, I; Othman, A; Penno, A; Saied, EM; Arenz, C; von Eckardstein, A; Hornemann, T

Hornemann, T (reprint author), Univ Zurich Hosp, Inst Clin Chem, CH-8091 Zurich, Switzerland.; Hornemann, T (reprint author), Univ Zurich, Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland.

JOURNAL OF LIPID RESEARCH, 2017; 58 (1): 60

Abstract

The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with a......

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