Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia

Bjelosevic, S; Gruber, E; Newbold, A; Shembrey, C; Devlin, JR; Hogg, SJ; Kats, L; Todorovski, I; Fan, Z; Abrehart, TC; Pomilio, G; Wei, A; Gregory, GP; Vervoort, SJ; Brown, KK; Johnstone, RW

Brown, KK (corresponding author), Peter MacCallum Canc Ctr, Canc Res Div, Level 12,305 Grattan St, Melbourne, Vic 3000, Australia.; Johnstone, RW (corresponding author), Peter MacCallum Canc Ctr, Gene Regulat Lab, 305 Grattan St, Melbourne, Vic 3000, Australia.

CANCER DISCOVERY, 2021; 11 (6): 1582

Abstract

Internal tandem duplication of the FMS-like tyrosine kinase 3 gene (FLT3-ITD) occurs in 30% of all acute myeloid leukemias (AML). Limited clinical eff......

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