Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics

Wolkenberg, SE; Nolt, MB; Bilodeau, MT; Trotter, BW; Manley, PJ; Kett, NR; Nanda, KK; Wu, ZC; Cato, MJ; Kane, SA; Kiss, L; Spencer, RH; Wang, JX; Lynch, JJ; Regan, CP; Stump, GL; Li, B; White, R; Yeh, SZ; Dinsmore, CJ; Lindsley, CW; Hartman, GD

Wolkenberg, SE (reprint author), Merck & Co Inc, Merck Res Labs, Dept Med Chem, POB 4, West Point, PA 19486 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (4): 1062

Abstract

Selective inhibition of Kv1.5, which underlies the ultra-rapid delayed rectifier current, I-Kur, has been pursued as a treatment for atrial fibrillati......

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