Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models

Liu, PW; Wang, CK; Chen, WH; Kang, Y; Liu, WW; Qiu, ZY; Hayashi, T; Mizuno, K; Hattori, S; Fujisaki, H; Ikejima, T

Ikejima, T (通讯作者),Shenyang Pharmaceut Univ, China Japan Res Inst Med & Pharmaceut Sci, Wuya Coll Innovat, 103 Wenhua Rd, Shenyang 110016, Peoples R China.

PHYTOMEDICINE, 2023; 109 ():

Abstract

Background: Over-activation of N-methyl-D-aspartate receptors (NMDARs) is involved in sporadic Alzheimer's disease. Silibinin, a natural flavonoid gai......

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