Trileucine residues in a ligand-CPP-based siRNA delivery platform improve endosomal escape of siRNA

Ullah, I; Chung, K; Beloor, J; Kim, J; Cho, M; Kim, N; Lee, KY; Kumar, P; Lee, SK

Lee, SK (reprint author), Hanyang Univ, Dept Bioengn, Seoul, South Korea.; Lee, SK (reprint author), Hanyang Univ, Inst Nanosci & Technol, Seoul, South Korea.; Kumar, P (reprint author), Yale Univ, Sch Med, Dept Internal Med, Infect Dis Sect, New Haven, C

JOURNAL OF DRUG TARGETING, 2017; 25 (4): 320

Abstract

siRNA entrapment within endosomes is a significant problem encountered with siRNA delivery platforms that co-opt receptor-mediated entry pathways. Att......

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