Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice

Sasaki, K; Hara, S; Yamakami, R; Sato, Y; Hasegawa, S; Kono, T; Morohaku, K; Obata, Y

Obata, Y (reprint author), Tokyo Univ Agr, Dept Biosci, Setagaya Ku, 1-1-1 Sakuragaoka, Tokyo 1568502, Japan.

MOLECULAR REPRODUCTION AND DEVELOPMENT, 2019; 86 (6): 614

Abstract

DNA methylation is generally known to inactivate gene expression. The DNA methyltransferases (DNMTs), DNMT3A and DNMT3B, catalyze somatic cell lineage......

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