The EGFR C797S Mutation Confers Resistance to a Novel EGFR Inhibitor CLN-081 to EGFR Exon 20 Insertion Mutations

Kagawa, Y; Hayashida, T; Liu, J; Mori, S; Izumi, H; Kumagai, S; Udagawa, H; Hattori, N; Goto, K; Kobayashi, SS

Kobayashi, SS (通讯作者),Beth Israel Deconess Med Ctr, Dept Med, Boston, MA 02215 USA.

JTO CLINICAL AND RESEARCH REPORTS, 2023; 4 (3):

Abstract

Introduction: EGFR exon 20 insertion mutations account for 5% to 10% of EGFR-mutated NSCLC. CLN-081 (formerly known as TAS6417), a novel covalent EGFR......

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