Determination of irinotecan, SN-38 and SN-38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients

Atasilp, C; Chansriwong, P; Sirachainan, E; Reungwetwattana, T; Puangpetch, A; Prommas, S; Sirilerttrakul, S; Rerkarmnuaychoke, B; Wongwaisayawan, S; Sukasem, C

Sukasem, C (reprint author), Mahidol Univ, Div Pharmacogen & Personalized Med, Dept Pathol, Fac Med,Ramathibodi Hosp, Bangkok, Thailand.

JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2018; 32 (1):

Abstract

BackgroundIrinotecan (CPT-11) is chemotherapy used mainly in the metastatic colorectal cancer. The purpose of this study was to develop and validate t......

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