Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke

Ma, FF; Sun, P; Zhang, XJ; Hamblin, MH; Yin, KJ

Yin, KJ (corresponding author), Univ Pittsburgh, Pittsburgh Inst Brain Disorders & Recovery, Dept Neurol, Sch Med, Pittsburgh, PA 15213 USA.; Yin, KJ (corresponding author), Vet Affairs Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15261 USA.

SCIENCE SIGNALING, 2020; 13 (626):

Abstract

The blood-brain barrier (BBB) maintains a stable brain microenvironment. Breakdown of BBB integrity during cerebral ischemia initiates a devastating c......

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