MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction-MedSci.cn

MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction

Elman, JA; Puckett, OK; Beck, A; Fennema-Notestine, C; Cross, LK; Dale, AM; Eglit, GML; Eyler, LT; Gillespie, NA; Granholm, EL; Gustavson, DE; Hagler, DJ; Hatton, SN; Hauger, R; Jak, AJ; Logue, MW; McEvoy, LK; McKenzie, RE; Neale, MC; Panizzon, MS; Reynolds, CA; Sanderson-Cimino, M; Toomey, R; Tu, XM; Whitsel, N; Williams, ME; Xian, H; Lyons, MJ; Franz, CE; Kremen, WS

Elman, JA (corresponding author), Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr,MC0738, La Jolla, CA 92093 USA.

Abstract

Introduction: The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the......

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MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction

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