Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis

Shide, K; Kameda, T; Kamiunten, A; Oji, A; Ozono, Y; Sekine, M; Honda, A; Kitanaka, A; Akizuki, K; Tahira, Y; Nakamura, K; Hidaka, T; Kubuki, Y; Abe, H; Miike, T; Iwakiri, H; Tahara, Y; Sueta, M; Hasuike, S; Yamamoto, S; Nagata, K; Ikawa, M; Shimoda,

Shimoda, K (reprint author), Univ Miyazaki, Fac Med, Dept Gastroenterol & Hematol, Miyazaki, Japan.; Shimoda, K (reprint author), Osaka Univ, Res Inst Microbial Dis, Dept Expt Genome Res, Suita, Osaka 5650871, Japan.

BLOOD CANCER JOURNAL, 2019; 9 ():

Abstract

Calreticulin (CALR) exon 9 frameshift mutations, commonly detected in essential thrombocythemia (ET) and primary myelofibrosis patients, activate sign......

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