Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader

Hu, LH; Li, HY; Qin, JL; Yang, D; Liu, JM; Luo, XM; Ma, JK; Luo, C; Ye, F; Zhou, YB; Li, J; Wang, ML

Zhou, YB; Li, J; Wang, ML (通讯作者),Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China.;Wang, ML (通讯作者),Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China.;Li, J (通讯作者),Zunyi Med Univ, Sch Pharm, Zunyi 563000, Guizhou, Peoples R China.;Li, J (通讯作者),Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China.;Wang, ML (通讯作者),Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China.;Zhou, YB; Li, J (通讯作者),Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China.;Ye, F (通讯作者),Zhejiang Sci Tech Univ, Coll Life Sci & Med, Hangzhou 310018, Peoples R China.

JOURNAL OF MEDICINAL CHEMISTRY, 2023; 66 (22): 15269

Abstract

Protein tyrosine phosphatase nonreceptor Type 2 (PTPN2) is an attractive target for cancer immunotherapy. PTPN2 and another subtype of PTP1B are highl......

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