Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling

Umstead, M; Xiong, JL; Qi, Q; Du, YH; Fu, HA

Fu, HA (reprint author), Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA.; Fu, HA (reprint author), Emory Univ, Sch Med, Emory Chem Biol Discovery Ctr, Atlanta, GA 30322 USA.; Fu, HA (reprint author), Winship Canc Inst, Atlanta, GA 30322 USA.

ONCOTARGET, 2017; 8 (17): 28359

Abstract

In cancer, upregulated Ras promotes cellular transformation and proliferation in part through activation of oncogenic Ras-MAPK signaling. While direct......

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