The primordial differentiation of tumor-specific memory CD8+T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

Huang, QZ; Wu, X; Wang, ZM; Chen, XY; Wang, LS; Lu, YJ; Xiong, D; Liu, Q; Tian, YH; Lin, HY; Guo, JY; Wen, SQ; Dong, W; Yang, XF; Yuan, YC; Yue, ZL; Lei, S; Wu, Q; Ran, L; Xie, LYZ; Wang, YF; Gao, LQ; Tian, Q; Zhou, XY; Sun, BC; Xu, LF; Tang, ZH; Ye, LL

Tang, ZH (通讯作者),Sun Yat sen Univ, Zhongshan Sch Med, Guangzhou 510080, Peoples R China.;Xu, LF; Ye, LL (通讯作者),Third Mil Med Univ, Inst Immunol, Chongqing 400038, Peoples R China.;Sun, BC (通讯作者),Nanjing Univ, Affiliated Drum Tower Hosp, Med Sch, Dept Hepatobiliary Surg, Nanjing 210008, Peoples R China.;Sun, BC (通讯作者),Anhui Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Hefei 230022, Peoples R China.;Ye, LL (通讯作者),Changping Lab, Beijing 102206, Peoples R China.

CELL, 2022; 185 (22): 4049

Abstract

Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to unleash exhausted tumor -reac-tive CD8+ T cells in the tumor microenvironmen......

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