Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor-engineered T Cells

Drent, E; Poels, R; Ruiter, R; van de Donk, NWCJ; Zweegman, S; Yuan, HP; de Bruijn, J; Sadelain, M; Lokhorst, HM; Groen, RWJ; Mutis, T; Themeli, M

Themeli, M (reprint author), Univ Amsterdam, Med Ctr, VUmc, Boelelaan1117, NL-1081 HV Amsterdam, Netherlands.

CLINICAL CANCER RESEARCH, 2019; 25 (13): 4014

Abstract

Purpose: Targeting nonspecific, tumor-associated antigens (TAA) with chimeric antigen receptors (CAR) requires specific attention to restrict possible......

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