Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants

Offensperger, F; Muller, F; Jansen, J; Hammler, D; Gotz, KH; Marx, A; Sirois, CL; Chamberlain, SJ; Stengel, F; Scheffner, M

Scheffner, M (corresponding author), Univ Konstanz, Dept Biol, Constance, Germany.; Scheffner, M (corresponding author), Univ Konstanz, Konstanz Res Sch Chem Biol, Constance, Germany.

CELL CHEMICAL BIOLOGY, 2020; 27 (12): 1510

Abstract

Genetic aberrations of the UBE3A gene encoding the E3 ubiquitin ligase E6AP underlie the development of Angelman syndrome (AS). Approximately 10% of A......

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