Serial single-cell genomics reveals convergent subclonal evolution of resistance as patients with early-stage breast cancer progress on endocrine plus CDK4/6 therapy

Griffiths, JI; Chen, JF; Cosgrove, PA; O'Dea, A; Sharma, P; Ma, CT; Trivedi, M; Kalinsky, K; Wisinski, KB; O'Regan, R; Makhoul, I; Spring, LM; Bardia, A; Adler, FR; Cohen, AL; Chang, JT; Khan, QJ; Bild, AH

Bild, AH (corresponding author), City Hope Natl Med Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA 91010 USA.; Khan, QJ (corresponding author), Univ Kansas Med Ctr, Div Med Oncol, Westwood, KS USA.

NATURE CANCER, 2021; 2 (6):

Abstract

Combining cyclin-dependent kinase (CDK) inhibitors with endocrine therapy improves outcomes for patients with metastatic estrogen receptor-positive br......

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