V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer

Gao, YJ; Maria, A; Na, N; Paula, AD; Gorelick, AN; Hechtman, JF; Carson, J; Lefkowitz, RA; Weigelt, B; Taylor, BS; Zhao, HY; Reis-Filho, JS; de Stanchina, E; Rosen, N; Yao, Z; Yaeger, R

Yaeger, R (reprint author), Mem Sloan Kettering Canc Ctr, 300 East 66th St,10th Floor, New York, NY 10065 USA.

CANCER DISCOVERY, 2019; 9 (9): 1182

Abstract

We report the emergence of the novel MEK1(V211D) gatekeeper mutation in a patient with BRAF(K601E) colon cancer treated with the allosteric MEK inhibi......

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