The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1(+/-) lymphoblastoid cells

Bourton, EC; Ahorner, PA; Plowman, PN; Zahir, SA; Al-Ali, H; Parris, CN

Parris, CN (reprint author), Anglia Ruskin Univ, Fac Sci & Technol, Dept Biomed & Forens Sci, East Rd, Cambridge CB1 1PT, Cambs, England.

JOURNAL OF CANCER, 2017; 8 (19): 4048

Abstract

The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while ......

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