Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes

He, XB; Xia, QS; Shi, Q; Fu, PP

Fu, PP (corresponding author), US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS, 2020; 38 (2): 109

Abstract

Pyrrolizidine alkaloids (PAs) are hepatotoxic, genotoxic, and carcinogenic phytochemicals. Upon metabolic activation, PAs produce dehydropyrrolizidine......

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