CD226 opposes TIGIT to disrupt Tregs in melanoma

Fourcade, J; Sun, ZJ; Chauvin, JM; Ka, M; Davar, D; Pagliano, O; Wang, H; Saada, S; Menna, C; Amin, R; Sander, C; Kirkwood, JM; Korman, AJ; Zarour, HM

Fourcade, J; Zarour, HM (reprint author), UPMC, Hillman Canc Ctr, Res Pavil,Suite 1-32a,5117 Ctr Ave, Pittsburgh, PA 15213 USA.

JCI INSIGHT, 2018; 3 (14):

Abstract

CD4(+) Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell ......

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