Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation

Chandra, B; Michmerhuizen, NL; Shirnekhi, HK; Tripathi, S; Pioso, BJ; Baggett, DW; Mitrea, DM; Iacobucci, I; White, MR; Chen, JJ; Park, CG; Wu, HY; Pounds, S; Medyukhina, A; Khairy, K; Gao, QS; Qu, CX; Abdelhamed, S; Gorman, SD; Bawa, S; Maslanka, C; Kinger, S; Dogra, P; Ferrolino, MC; Di Giacomo, D; Mecucci, C; Klco, JM; Mullighan, CG; Kriwacki, RW

Mullighan, CG (通讯作者)，St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA.;Kriwacki, RW (通讯作者)，St Jude Childrens Res Hosp, 262 Danny Thomas Pl, Memphis, TN 38105 USA.

CANCER DISCOVERY, 2022; 12 (4): 1152

Abstract

NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform hematopoietic cells. Most NUP98 FOs harbor an intrinsically disor......

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