JAK Mutations as Escape Mechanisms to Anti-PD-1 Therapy

Marabelle, A; Aspeslagh, S; Postel-Vinay, S; Soria, JC

Soria, JC (reprint author), Inst Gustave Roussy, 114 Rue Edouard Vaillant, F-98105 Villejuif, France.; Soria, JC (reprint author), Univ Paris Sud, 114 Rue Edouard Vaillant, F-98105 Villejuif, France.

CANCER DISCOVERY, 2017; 7 (2): 128

Abstract

JAK mutations could be one of the primary escape mechanisms to anti-PD-1/PD-L1 immunotherapy via impaired IFN gamma signaling in cancer cells and coul......

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