Induction of the activating transcription factor-4 in the intratumoral CD8+T cells sustains their viability and anti-tumor activities

Lu, Z; Bae, EA; Verginadis, II; Zhang, HR; Cho, C; McBrearty, N; George, SS; Diehl, JA; Koumenis, C; Bradley, LM; Fuchs, SY

Fuchs, SY (通讯作者)，Univ Penn, Sch Vet Med, Dept Biomed Sci, 380 S Univ Ave,Hill 316, Philadelphia, PA 19104 USA.

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2023; 72 (4): 815

Abstract

Immune suppressive factors of the tumor microenvironment (TME) undermine viability and exhaust the activities of the intratumoral cytotoxic CD8 + T ly......

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