Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human TNNT2 Variants

Pettinato, AM; Ladha, FA; Mellert, DJ; Legere, N; Cohn, R; Romano, R; Thakar, K; Chen, YS; Hinson, JT

Hinson, JT (corresponding author), UConn Hlth, 10 Discovery Dr, Farmington, CT 06032 USA.; Hinson, JT (corresponding author), Jackson Lab Genom Med, 10 Discovery Dr, Farmington, CT 06032 USA.

CIRCULATION, 2020; 142 (23): 2262

Abstract

Background: Pathogenic TNNT2 variants are a cause of hypertrophic and dilated cardiomyopathies, which promote heart failure by incompletely understood......

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