Mechanistic Pharmacokinetic/Pharmacodynamic Modeling in Support of a Patient-Convenient, Longer Dosing Interval for Carfilzomib, a Covalent Inhibitor of the Proteasome

Yago, MR; Mehta, K; Bose, M; Bhagwat, S; Chopra, VS; Dutta, S; Upreti, VV

Upreti, VV (通讯作者),Amgen Inc, Clin Pharmacol Modeling & Simulat, San Francisco, CA 94080 USA.

CLINICAL PHARMACOKINETICS, 2023; 62 (5): 779

Abstract

BackgroundCarfilzomib is an irreversible second-generation proteasome inhibitor that has a short elimination half-life but much longer pharmacodynamic......

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