Crystallographic landscape of SHP2 provides molecular insights for SHP2 targeted drug discovery

Song, YH; Yang, XY; Wang, S; Zhao, M; Yu, B

Yu, B (通讯作者)，Zhengzhou Univ, Sch Pharmaceut Sci, Sci Rd 100, Zhengzhou 450001, Henan, Peoples R China.

MEDICINAL RESEARCH REVIEWS, 2022; 42 (5): 1781

Abstract

The protein tyrosine phosphatase SHP2 encoded by PTPN11 is a promising therapeutic target for cancer therapy. The dynamic change of SHP2 between close......

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