AUY922 induces retinal toxicity through attenuating TRPM1

Shen, CH; Hsieh, CC; Jiang, KY; Lin, CY; Chiang, NJ; Li, TW; Yen, CT; Chen, WJ; Hwang, DY; Chen, LT

Shen, CH; Chen, LT (corresponding author), Natl Hlth Res Inst, Natl Inst Canc Res, 367 Sheng Li Rd, Tainan 70456, Taiwan.; Chen, LT (corresponding author), Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Oncol, Tainan 704, Taiwan.; Chen, LT (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung 807, Taiwan.; Shen, CH (corresponding author), Natl Chung Hsing Univ, Biotechnol Ctr, PhD Program Tissue Engn & Regenerat Med, Taichung 402, Taiwan.

JOURNAL OF BIOMEDICAL SCIENCE, 2021; 28 (1):

Abstract

Background Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pa......

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