A novel EGFR inhibitor acts as potent tool for hypoxia-activated prodrug systems and exerts strong synergistic activity with VEGFR inhibition in vitro and in vivo

Caban, M; Koblmueller, B; Groza, D; Schueffl, HH; Terenzi, A; Tolios, A; Mohr, T; Mathuber, M; Kryeziu, K; Jaunecker, C; Pirker, C; Keppler, BK; Berger, W; Kowol, CR; Heffeter, P

Heffeter, P (通讯作者)，Med Univ Vienna, Ctr Canc Res, Borschkegasse 8A, A-1090 Vienna, Austria.

CANCER LETTERS, 2023; 565 ():

Abstract

Small-molecule EGFR inhibitors have distinctly improved the overall survival especially in EGFR-mutated lung cancer. However, their use is often limit......

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