Lipoxin A4 protects against paraquat-induced acute lung injury by inhibiting the TLR4/MyD88-mediated activation of the NF-kappa B and PI3K/AKT pathways

Li, YH; Wang, N; Ma, ZL; Wang, YW; Yuan, Y; Zhong, ZT; Hong, Y; Zhao, M

Zhao, M (corresponding author), China Med Univ, Shengjing Hosp, Dept Emergency Med, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (5):

Abstract

Paraquat (PQ) causes serious oxidative stress and inflammatory responses, particularly to the lungs. Since lipoxin A4 (LXA4) functions as an anti-infl......

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