Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation

Saifuzzaman, M; Morrison, R; Zheng, ZH; Orive, S; Hamilton, J; Thompson, PE; Al-rawi, JMA

Al-rawi, JMA (reprint author), La Trobe Univ, La Trobe Inst Mol Sci, Pharm & Appl Sci, POB 199, Bendigo, Vic 3552, Australia.

BIOORGANIC & MEDICINAL CHEMISTRY, 2017; 25 (20): 5531

Abstract

A series of 40 7-(O-substituted)-2-morpholino-8-aryl-4H-benzo[e][1,3]oxazin-4-one derivatives was synthesized. They were prepared via synthesis of a k......

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