Discovery of 6-(pyrimidin-5-ylmethyl)quinoline-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5

Felts, AS; Rodriguez, AL; Morrison, RD; Blobaum, AL; Byers, FW; Daniels, JS; Niswender, CM; Conn, PJ; Lindsley, CW; Emmitte, KA

Emmitte, KA (reprint author), Univ North Texas Hlth Sci Ctr, UNT Syst Coll Pharm, Dept Pharmaceut Sci, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018; 28 (10): 1679

Abstract

Based on previous work that established fused heterocycles as viable alternatives for the picolinamide core of our lead series of mGlu(5) negative all......

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