Transcriptional control of CBX5 by the RNA-binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia

Prieto, C; Nguyen, DTT; Liu, ZQ; Wheat, J; Perez, A; Gourkanti, S; Chou, T; Barin, E; Velleca, A; Rohwetter, T; Chow, A; Taggart, J; Savino, AM; Hoskova, K; Dhodapkar, M; Schurer, A; Barlowe, TS; Vu, LP; Leslie, C; Steidl, U; Rabadan, R; Kharas, MG

Kharas, MG (corresponding author), Mem Sloan Kettering Canc Ctr, Mol Pharmacol Program, 1275 York Ave, New York, NY 10021 USA.; Kharas, MG (corresponding author), Mem Sloan Kettering Canc Ctr, Ctr Cell Engn, Ctr Stem Cell Biol, Ctr Expt Therapeut,Ctr Hematol Malignancies, 1275 York Ave, New York, NY 10021 USA.

NATURE CANCER, 2021; 2 (7): 741

Abstract

Kharas and colleagues identify the RNA-binding proteins RBMX and RBMXL1 as AML tumor promoters that alter chromatin compaction and hence cell survival......

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