Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction

Sillen, M; Weeks, SD; Zhou, XH; Komissarov, AA; Florova, G; Idell, S; Strelkov, SV; Declerck, PJ

Declerck, PJ (corresponding author), Katholieke Univ Leuven, Lab Therapeut & Diagnost Antibodies, Dept Pharmaceut & Pharmacol Sci, O&N2,Herestr 49,PB 820, B-3000 Leuven, Belgium.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020; 18 (3): 681

Abstract

Background Plasminogen activator inhibitor-1 (PAI-1), a key inhibitor of plasminogen activators (PAs) tissue-type PA (tPA) and urokinase-type PA (uPA)......

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