CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators

Fang, L; Wang, W; Li, GP; Zhang, L; Li, J; Gan, DW; Yang, J; Tang, YS; Ding, ZW; Zhang, M; Zhang, WH; Deng, DQ; Song, ZY; Zhu, QH; Cui, HH; Hu, YH; Chen, W

Fang, L; Chen, W (corresponding author), Southern Univ Sci & Technol, Dept Biol, Shenzhen, Guangdong, Peoples R China.; Fang, L; Chen, W (corresponding author), Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen, Guangdong, Peoples R China.

MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (11):

Abstract

Cellular RNA is decorated with over 170 types of chemical modifications. Many modifications in mRNA, including m(6)A and m(5)C, have been associated w......

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