In silicoandin vitrometabolism of ribociclib: a mass spectrometric approach to bioactivation pathway elucidation and metabolite profiling

Alsubi, TA; Attwa, MW; Bakheit, AH; Darwish, HW; Abuelizz, HA; Kadi, AA

Darwish, HW (corresponding author), King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia.; Darwish, HW (corresponding author), Cairo Univ, Fac Pharm, Analyt Chem Dept, Kasr El Aini St, Cairo 11562, Egypt.

RSC ADVANCES, 2020; 10 (38): 22668

Abstract

Ribociclib (RBC, Kisqali (R)) is a highly selective CDK4/6 inhibitor that has been approved for breast cancer therapy. Initially, prediction of suscep......

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