Diclofenac exhibits cytotoxic activity associated with metabolic alterations and p53 induction in ESCC cell lines and decreases ESCC tumor burden in vivo

Kabir, MF; Jackson, JL; Fuller, AD; Gathuka, L; Karami, AL; Conde, DG; Klochkova, A; Mu, AB; Cai, KQ; Klein-Szanto, AJ; Muir, AB; Whelan, KA

Whelan, KA (通讯作者)，Temple Univ, Lewis Katz Sch Med, Fels Canc Inst Personalized Med, 3307 N Broad St,PAHB Room 206, Philadelphia, PA 19140 USA.

CARCINOGENESIS, 2023; 44 (2): 182

Abstract

Here, we identify the non-steroidal anti-inflammatory drug diclofenac as an effective experimental therapeutic for ESCC tumors in vivo. We further doc......

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