Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma

Bevill, SM; Casaní-Galdón, S; El Farran, CA; Cytrynbaum, EG; Macias, KA; Oldeman, SE; Oliveira, KJ; Moore, MM; Hegazi, E; Adriaens, C; Najm, FJ; Demetri, GD; Cohen, S; Mullen, JT; Riggi, N; Johnstone, SE; Bernstein, BE

Bernstein, BE (通讯作者),Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.;Johnstone, SE; Bernstein, BE (通讯作者),Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Bernstein, BE (通讯作者),Harvard Med Sch, Dept Cell Biology, Boston, MA 02115 USA.;Bernstein, BE (通讯作者),Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA.;Johnstone, SE (通讯作者),Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA.;Johnstone, SE (通讯作者),Dana Farber Canc Inst, Dept Pathol, Boston, MA 02215 USA.;Bernstein, BE (通讯作者),Harvard Med Sch, Ludwig Ctr Harvard, Boston, MA 02115 USA.

CELL GENOMICS, 2023; 3 (7):

Abstract

Amplification of MDM2 on supernumerary chromosomes is a common mechanism of P53 inactivation across tumors. Here, we investigated the impact of MDM2 o......

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