Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer

Zhai, TH; Wang, C; Xu, YF; Huang, WF; Yuan, ZJ; Wang, T; Dai, S; Peng, SG; Pang, TL; Jiang, WC; Huang, YH; Zou, YF; Xu, YD; Sun, JN; Gong, XJ; Zhang, JP; Tsun, A; Li, B; Miao, XN

Li, B (corresponding author), Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Dept Immunol & Microbiol, Sch Med, Shanghai, Peoples R China.; Miao, XN (corresponding author), Biotheus Inc, Discovery Biol & Discovery Technol, Zhuhai, Peoples R China.; Miao, XN (corresponding author), Soochow Univ, Inst Biol, Suzhou, Peoples R China.; Miao, XN (corresponding author), Soochow Univ, Inst Med Sci, Suzhou, Peoples R China.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (6):

Abstract

Background The discovery of checkpoint inhibitors towards cytotoxic T-lymphocyte protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) has bee......

Full Text Link