Discovery of Arylsulfonamide Na(v)1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

Roecker, AJ; Layton, ME; Pero, JE; Kelly, MJ; Greshock, TJ; Kraus, RL; Li, YX; Klein, R; Clements, M; Daley, C; Jovanovska, A; Ballard, JE; Wang, DP; Zhao, FQ; Brunskill, APJ; Peng, XJ; Wang, X; Sun, HY; Houghton, AK; Burgey, CS

Roecker, AJ (corresponding author), Merck & Co Inc, Discovery Chem, West Point, PA 19486 USA.

ACS MEDICINAL CHEMISTRY LETTERS, 2021; 12 (6): 1038

Abstract

The voltage-gated sodium channel Na(v)1.7 continues to be a high-profile target for the treatment of various pain afflictions due to its strong human ......

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