Dasatinib overcomes stroma-based resistance to the FLT3 inhibitor quizartinib using multiple mechanisms

Patel, AB; Pomicter, AD; Yan, DQ; Eiring, AM; Antelope, O; Schumacher, JA; Kelley, TW; Tantravahi, SK; Kovacsovics, TJ; Shami, PJ; O'Hare, T; Deininger, MW

Deininger, MW (corresponding author), Univ Utah, Div Hematol & Hematol Malignancies, Salt Lake City, UT 84112 USA.; Deininger, MW (corresponding author), Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA.

LEUKEMIA, 2020; 34 (11): 2981

Abstract

FLT3-ITD mutations occur in 20-30% of AML patients and are associated with aggressive disease. Patients with relapsed FLT3-mutated disease respond wel......

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