SIRT1 regulates O-GlcNAcylation of tau through OGT

Lu, S; Yin, XM; Wang, J; Gu, Q; Huang, Q; Jin, NN; Chu, DD; Xu, ZQ; Liu, F; Qian, W

Qian, W (corresponding author), Med Sch, Dept Biochem & Mol Biol, Nantong, Jiangsu, Peoples R China.; Qian, W (corresponding author), Nantong Univ, Jiangsu Key Lab Neuroregenerat Jiangsu, Coinnovat Ctr Neuroregenerat, Nantong, Jiangsu, Peoples R China.; Qian, W (corresponding author), Nantong Univ, Minist Educ China, Coinnovat Ctr Neuroregenerat, Nantong, Jiangsu, Peoples R China.

AGING-US, 2020; 12 (8): 7042

Abstract

Tau is modified with O-GlcNAcylation extensively in human brain. The O-GIcNAcylation levels of tau are decreased in Alzheimer's disease (AD) brain. Si......

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