Design, synthesis, and biological evaluation of a potent PLK4 inhibitor WY29 with 1H-pyrazolo[3,4-d]pyrimidine scaffold

Wang, L; Sun, Y; Wang, JK; Xue, YL; Sun, Y; Qin, QH; Sun, YX; Zhao, DM; Cheng, MS

Zhao, DM (通讯作者)，Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China.

ARCHIV DER PHARMAZIE, 2023; 356 (3):

Abstract

Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4). Overexpression of PLK4 in somatic cells can lead to th......

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