Hypersensitivity reactions to asparaginase in mice are mediated by anti-asparaginase IgE and IgG and the immunoglobulin receptors Fc epsilon RI and Fc gamma RIII

Rathod, S; Ramsey, M; Relling, MV; Finkelman, FD; Fernandez, CA

Fernandez, CA (reprint author), Univ Pittsburgh, Ctr Pharmacogenet, Pittsburgh, PA 15260 USA.; Fernandez, CA (reprint author), Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15260 USA.

HAEMATOLOGICA, 2019; 104 (2): 319

Abstract

Asparaginase is an important drug for the treatment of leukemias. However, anti-asparaginase antibodies often develop, which can decrease asparaginase......

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