Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

Malik, AU; Karapetsas, A; Nirujogi, RS; Mathea, S; Chatterjee, D; Pal, P; Lis, P; Taylor, M; Purlyte, E; Gourlay, R; Dorward, M; Weidlich, S; Toth, R; Polinski, NK; Knapp, S; Tonelli, F; Alessi, DR

Tonelli, F; Alessi, DR (corresponding author), Univ Dundee, Sch Life Sci, Med Res Council MRC, Prot Phosphorylat & Ubiquitylat Unit, Dow St, Dundee DD1 5EH, Scotland.

BIOCHEMICAL JOURNAL, 2021; 478 (3): 553

Abstract

Autosomal dominant mutations in LRRK2 that enhance kinase activity cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases including R......

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